Ben Burgess' 91st minute goal clinched it for Blackpool, on a disappointing afternoon for the R's.
The Seasiders' front-man headed past the otherwise outstanding Lee Camp in the first minute of stoppage time, to send Rangers back to the Capital with nothing to show for their efforts.
The R's, to their credit, worked tirelessly, but the swirling wind made it almost impossible for the visitors to play the expansive football the Rangers faithful have become accustomed to in recent weeks.
Michael Mancienne (hamstring), Sampsa Timoska (ill) and Dexter Blackstock (suspended) all missed out, while there was no place in the 16 for number two keeper Jake Cole (ill).
Akos Buzsaky shook off a dead leg to start, while Bob Malcolm, Adam Bolder and Ben Sahar returned to the starting XI.
Rookie goalkeeper Chris Goodchild was named amongst the R's substitutes and so to was Stefan Moore, after Danny Nardiello picked up a knock in the warm-up.
Former R's defender Ian Evatt was named on the Seasiders bench, after a ten-week injury absence.
Rangers were almost ahead inside the opening 43 seconds.
Martin Rowlands, linking up well from right back, played a neat pass into Rowan Vine, who saw his right footed effort deflected inches wide.
Buzsaky's resultant corner forced Seasiders keeper Paul Rachubka to tip the ball over his crossbar, as the R's came out the blocks at an electrifying rate.
Despite their impressive start, it was Camp who earned an ovation from travelling faithful midway through the half.
Burgess seemed destined to break the deadlock when he was gifted time and space to execute a volley from the edge of the six-yard box, but Camp stood up well, tipping the ball to safety.
Burgess was the liveliest player on the park, peeling away from his marker before letting fly from distance five minutes later.
Camp seemed confident enough that he had the shot covered though, raising his right arm as a token gesture as the ball flew a yard or so over his crossbar.
The only other chance of note during a disappointing half saw Vine sting the palms of Rachubka from distance.
Sensing the three points were theirs for the taking, Rangers brought on man-mountain Marc Nygaard in place of Sahar at the break.
On possibly the coldest afternoon of the season so far, a dozen or so of the 1,000-plus travelling Rangers fans marked the arrival of the Great Dane by baring their chests and doing the conga up and down the aisles of the East Stand.
Crazy? Stupid? Call it what you will - but committed probably best about summed it up.
With the clock ticking towards the hour and conditions worsening by the minute, both sides continued to struggle to pose any attacking threat of note.
Buzsaky fired high and wide from an acute angle, before Seasiders' substitute Andy Morrell failed to get his shot away after being teed up by Claus Jorgensen.
The same player squandered a golden chance to give Blackpool the lead 16 minutes from time, firing straight at Camp after Rangers were guilty of switching off from a quickly taken free-kick.
Blackpool, to their credit, improved as the half wore on, but their inability to create ultimately proved to be their downfall.
Morrell and Burgess each made poor decisions in vital areas, while at the other end, the R's were restricted to counter-attacks at best.
Camp enhanced his ever-growing reputation with a smart, point-blank save from Burgess, but there was nothing the R's number one could do to prevent Blackpool clinching it at the death.
Gifted the freedom of the 18-yard box, the gangly striker headed past an exposed Camp, in the first minute of added time.
Blackpool: Rachubka, Crainey, Southern (Fox 12), Jackson, Hoolahan, Jorgensen, Gorkss, Welsh (Taylor-Fletcher 60), Barker, Burgess, Slusarski (Morrell 54).
Subs: Evatt, Parker.
Scorers: Burgess 90
Bookings:
Red Cards:
QPR: Camp, Barker, Stewart, Bolder, Buzsaky (Moore 77), Rowlands, Malcolm, Vine (Ainsworth 69), Sahar (Nygaard 46), Leigertwood, Sinclair.
Subs: Bailey, Goodchild.
Scorers:
Bookings: Buzsaky 76, Rowlands 80
Red Cards:
Referee: Mr C Oliver
Attendance: 8, 527 (1, 063)
